PARP-mediated repair, homologous recombination, and back-up non-homologous end joining-like repair of single-strand nicks
نویسندگان
چکیده
منابع مشابه
PARP-mediated repair, homologous recombination, and back-up non-homologous end joining-like repair of single-strand nicks.
Double-strand breaks (DSBs) in chromosomal DNA can induce both homologous recombination (HR) and non-homologous end-joining (NHEJ). Recently we showed that single-strand nicks induce HR with a significant reduction in toxicity and mutagenic effects associated with NHEJ. To further investigate the differences and similarities of DSB- and nick-induced repair, we used an integrated reporter system...
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In spite of its essential role as the carrier of genetic information, DNA is not an inert structure. The genome is susceptible to potentially mutagenic threats of both endogenous and environmental origin. A dramatic threat to the covalent structure of DNA is posed by breaks in the phosphate backbone affecting one or both strands of the Watson–Crick double helix. Ionizing radiation and certain c...
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ژورنال
عنوان ژورنال: DNA Repair
سال: 2013
ISSN: 1568-7864
DOI: 10.1016/j.dnarep.2013.04.004